| Although drugs in traditional Chinese medicine (TCM) from plant and animal sources
are recognized 25 valuable für therapies there is a need for quality control, safety
assessment and pharmacological evaluation to profe safety and efficacy. The
identification of active compounds and their molecular mechanism an drug targets is
important. State-of-the-art analytical methods, such as mass spectrometry and
HPLC, are highly useful tools for elucidation and standardization of TCM drugs.
In this project the aim of the analyses was to evaluate TCM drugs an efficacy,
therapeutical quality and modernization.
In the fist part we summarized the influences of different treatments like paozhi
processing an Chinese herbal medicines (part 1).
In the following parts efficacy and therapeutical quality af Chinese herbal medicines
(CHMs) were investigated. Thereby, extracts from CHMs were tested an drug targets
involved in metabolic disorders and inflammatian. Selected bioactive extracts were
further investigated für active compounds (part 2, part 3).
In the final part the results an the modernization of a Chinese herbal formulation are
described (part 4).
In conclusion, this project encompassed studies which provided evidence
based research of safety, efficacy and therapeutical quality as well as
modernization of TCM drugs/preparations.
The research project resulted in 4 publications that were published in top 25%
journals (lF 2.4- 33.61 — see Science 2015) and further publications, that are
submitted (manuscript of part 3) or in preparation.
|